Which Covid vaccine is the best? Which Covid vaccine is the most effective? How do we measure vaccine effectiveness? Do Covid vaccines work against new variants? Is it possible that Covid vaccines may make things worse in the future?

I answer all of these questions in this video. First, we compare the seven vaccines that have published phase 3 trial data as of June 2021. Those include Pfizer, Moderna, Sputnik, Johnson & Johnson, Sinopharm, and AstraZeneca. I look at the phase 3 trial data published in peer-reviewed journals.

I compare the vaccine effectiveness between each vaccine. I also look at the differences in the phase III studies and see that the SARS-CoV-2 variants probably explain the differences in the vaccines. Each vaccine becomes less effective against variants that have more mutations, especially mutations on the spike protein, such as the E484K mutation, which can cause immune escape. Important mutations discussed include the South African variant, B.1.351, the Brazil variant, P.1, the UK variant, B.1.1.7, and the Indian variant, B.1.167.

Finally, I explain why this matters. Countries, such as Thailand, Vietnam, and Malaysia, that have not yet had widespread Covid outbreaks may not be able to effectively use vaccines to prevent future outbreaks, as the current vaccines have substantially reduced effectiveness against the variants in those countries. I also explore the possibility that vaccines may initiate antibody-dependent enhancement, or ADE, which may make future infections worse for some people.

0:00 Introduction
0:53 How do we measure the effectiveness of a vaccine?
2:13 Which Covid vaccines have published phase 3 trial data?
3:36 How effective were Covid vaccines in phase 3 trials?
5:48 How much do virus variants reduce vaccine efficacy?
9:46 Not all effectiveness results can be compared
10:30 The most vaccinated country had a Covid outbreak
12:11 Possibility of future antibody-dependent enhancement

For further reading:

Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults
A Randomized Clinical Trial | https://doi.org/10.1001/jama.2021.8565

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine | https://doi.org/10.1056/NEJMoa2035389

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | https://doi.org/10.1056/NEJMoa2034577

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 | https://doi.org/10.1056/NEJMoa2101544

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia | https://doi.org/10.1016/S0140-6736(21)00234-8

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | https://doi.org/10.1016/S0140-6736(20)32661-1

Effectiveness of COVID-19 vaccines against the B.1.617.2 variant | https://khub.net/documents/135939561/430986542/Effectiveness+of+COVID-19+vaccines+against+the+B.1.617.2+variant.pdf/204c11a4-e02e-11f2-db19-b3664107ac42

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117967/pdf/NEJMc2104974.pdf

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies | https://www.nature.com/articles/s41564-020-00789-5.pdf

Antibody-dependent Enhancement (ADE) and Vaccines | https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-safety/antibody-dependent-enhancement-and-vaccines

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By earmpy

39 thoughts on “Which Covid vaccine is the best? | Vaccine Effectiveness and Variants Explained”
  1. It's a miracle that I am alive today. I encountered HERPES SIMPLEX VIRUS (HSV1 / 2) for four (4) years, And BAD BREATH (Halitosis) At 26, and without warning, my breath began its rapid descent towards face-melting foulness. I started to notice that people were beginning to stand quite far away from me when I spoke, before I met Dr abumere. I am from los angeles California, united state of America. Herpes is a viral infection caused by the Herpes simplex virus, marked by painful, watery blisters in the skin or mucous membrane or on the genitals. This was what I suffered for four years. I have visited CVS Pharmacy in CA for treatment but no improvement. I met Dr abumere online while I was searching for a herpes cure. II read a testimony about his work. I gave him a try and it turns to a testimony in my life. Just after two days (2) taking the medicine as directed by him i began to see some good change, my breath was noticeably fresher and cleaner – and more importantly, me hsv1 / 2 is gone. My report came out negative, all thanks to God. my "Dragon Breath" hasn't returned since … You too can contact Dr abumere WhatsApp +2349021975055 or E-mail: (doctorabumrer6@gmail.com) thank you .

  2. It's a miracle that I am alive today. I encountered HERPES SIMPLEX VIRUS (HSV1 / 2) for four (4) years, And BAD BREATH (Halitosis) At 26, and without warning, my breath began its rapid descent towards face-melting foulness. I started to notice that people were beginning to stand quite far away from me when I spoke, before I met Dr abumere. I am from los angeles California, united state of America. Herpes is a viral infection caused by the Herpes simplex virus, marked by painful, watery blisters in the skin or mucous membrane or on the genitals. This was what I suffered for four years. I have visited CVS Pharmacy in CA for treatment but no improvement. I met Dr abumere online while I was searching for a herpes cure. II read a testimony about his work. I gave him a try and it turns to a testimony in my life. Just after two days (2) taking the medicine as directed by him i began to see some good change, my breath was noticeably fresher and cleaner – and more importantly, me hsv1 / 2 is gone. My report came out negative, all thanks to God. my "Dragon Breath" hasn't returned since … You too can contact Dr abumere WhatsApp +2349021975055 or E-mail: (doctorabumrer6@gmail.com) thank you

  3. Everything is useless for this variant wuhan virus .. Same stuff in different Names to deceive people …This is only experimental synthetic. Gene therapy ..Pharmaceutical companies are business minded people ..We need 5 to 10 years to.do research to make effective vaccine …From EU .

  4. #The unvaccinated human immune system, is the best place to start.

    It got mankind through the 1918 Spanish Flu pandemic, as bad as it was.
    No Iphones, LCD panels, virtually no personal communication devices back then,
    no penicillin, no PayWave, and no climate control apps.

    Though mankind in 1918 heard more of the 'Truth'
    Truth is Golden.

  5. Great job on putting together the researched info here…… hate the way everything is rated in the info provided…. 14 days for efficacy rating is excessively fast which makes one think how much of the body's natural steps are bypassed …. for instance J&J starts a few steps back making the body do more of the work (which takes longer) and as a result the body creates more T-Cells which enhances the immune systems strength and effects against covid is my understanding (some of said over 90% efficacy after 28 days) and with it having more of a diverse sample world wide could be possibly more effective against variants….. and if this is the case then ultimately all vaccines could all have the same efficacy after 28 days but given some bypass many of the body's natural steps (resulting in fewer T-cells) then will that have an effect for long term protection…. so many rabbit holes to go down … great job putting this together though I restrain from saying any of these are better than the other given the way they were all not tested exactly the same as others but this does help everyone come to their own conclusion easier…… damn those studies are hard to go through.

  6. Structural racism? Who are these guys just more shills pushing the narrative In this disgusting country today. You don’t “not get the care you need “ because you say in the back of the bus😂🤦🏼‍♀️🤬 These guys should be ashamed of themselves! Can you get the care you get depending on where are you live in the country. Close doctors are a joke these days and just straight up indoctrinated into believing they’re doing good but their whole ENTIRE career they’ve been deceived by a higher up indoctrinated system pushing more lies for big Pharma to make even more BILLIONS off its own people just for MONEY! Money makes these psychopaths do crazy 💩 just to control and have power over you and your health. Why doesn’t anybody looking to a study? And who funds these disgusting corporations ruling our contra. It’s all one big circle and it’ll never stop! The whole world has been indoctrinated into believing bullshit lies that has zero science and evidence to back it up

  7. Dude thats too good man I appreciate your knowledge here , the way you presented everything in a 14 minutes video , thats insane bruh👍🥰
    Love from INDIA 🇮🇳

  8. The best vaccine is the one you don't take when you don't need it especially avoiding those that have no FDA approval and have not been tested overtime. Dr. Faucci needs a trial, a legal one

  9. The results of effectiveness that you show are related to "reducing severe covid19" not reduction of "infection". On the other hand, in the Pfizer submission to FDA they comment themselves that the reduction in severe covid was observed in such a small number of people that "no conclusion can be taken". + many other unscientific analysis in your video.

  10. if covid can infects human with weak immune system. so what are the causes to weaken our immune system? our not healthy food intakes 3 to 4 times daily, our gadgets like celphones mostly its 24 hours open. so the celphones are the most were using and carry every day. so what if we try to avoid this celphones to put in airplane mode in public places. now every corner of the cities have towers which transmits to your celphones that have electronic microwave radiation to human. 4g is more safer to 5g. above our air atmosphere there are thousands of communication satellites which also we experience in our country about some air travellers got infected upon arrival but upon departure they are in good health. thats why the WHO had protocol of social distancing due 80 percent of population had celphones. i think this vaccines are for their communication technologies business. there might be some hidden secrets. even bill gates had already predicted it a decade ago so he creates his vaccines advance. their scientific technologies are now used in warfare. every human carries bacteria in our mouth so if we have weak immune system we got sick just like tonsilities. tonsilities you can have fever, flu, headache, cough. just like covid. thats why the WHO says droplets cause infection to human. i think electronic microwave radiation pollution worldwide might get us sick. its still a mystery. the birds had detected it a decade ago they died while flying. no one had tested the birds. this is where 4g and celphones started used in 2009. lab leak theory can't infect air traveller cases. i think its communication satellite leak theory.

  11. COVlD-19 Bishal Bhagat CoronaVirus Vaccine Vaccination Oxygen ⚠⚠ ??? 👈👈😥😥😭😭😷😷🕔🕔🙏🙏📅📅🇮🇳🇮🇳🏡🏡🚶🚶🏃🏃🌍🌍🔥🔥🔥

  12. “The government is not protecting anyone from the virus.
    The government is the virus, masquerading as its own cure.”
    -Brian (HighImpactFlix)

  13. Lysenkoism: describes the manipulation or distortion of the scientific process
    as a way to reach a predetermined conclusion as dictated by an ideological bias,
    often related to social or political objective.
    -wikipedia

  14. I am really happy for watching this video to be clear all different vaccinations and there effects as I have not take my injection yet👏😀🙌😄👌 thank you so much for all your explanations👍👍👍

  15. No matter what we still need to be vaccinated. Even though you don’t have a bulletproof vest at the very least should have a piece of metal in front of you rather than nothing.

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